Paneth Cells and Lgr5+ Intestinal Stem Cells in Radiation Enteritis

Cancer is the leading cause of death in adults and majority cancers involve abdominal pelvic organs. Radiotherapy used management around half patients who have malignancies 70% treated will develop radiation enteritis. The onset enteritis may delay completion treatment or lead to life-threatening conditions such as bowel perforation obstruction. High-dose ionizing can affect all layers small intestine weakening its structural integrity, dysbiosis, malabsorption, derangement innate immunity. Advances cancer has not led an improvement available preventative options are still ineffective. Severe acute chronic result from damage crypt-based intestinal stem cells their derivatives, which include Paneth cells. regulate proliferation differentiation other roles protection nourishment cells, control gut microbiota. also de-differentiate replace irreversibly damaged This article reviews anatomy epithelium epithelial including effect on knowledge be effective discussed.